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Hepatic effects that are considered adverse include death, abnormal clinical chemistry parameters, obvious functional organ impairment, DNA and mitochondrial alteration, glutathione depletion, hepatocyte necrosis, enhanced replicative DNA synthesis, generation of reactive oxygen species, and increased peroxisome proliferation (in rodents) (Williams and Iatropoulos 2002)

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A 37-amino acid long-acting acylated amylin analog that activates amylin and calcitonin receptors to modulate appetite signaling in homeostatic and hedonic brain regions, studied in clinical trials for weight management

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Post-discontinuation, 19.6 % restarted the original medication, while 35 % adopted another option: alternative medication (27.4 %), healthcare visit for lifestyle modification (13.7 %), and metabolic and bariatric surgery (0.6 %)

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